When should you not take Zofran?
low amount of potassium in the blood. extrapyramidal disease, a type of movement disorder. neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion. serotonin syndrome, a type of disorder with high serotonin levels.
Is Zofran a CYP3A4 inhibitor?
In vitro metabolism studies have shown that ondansetron is a substrate for human hepatic cytochrome P-450 enzymes, including CYP1A2, CYP2D6, and CYP3A4. In terms of overall ondansetron turnover, CYP3A4 played the predominant role.
What’s the max amount of Zofran you can take?
The single intravenous dose must not exceed 8 mg. Oral dosing can commence 12 hours later and may be continued for up to 5 days (Table 1). The total dose over 24 hours (given as divided doses) must not exceed adult dose of 32 mg.
Why you shouldn’t take Zofran?
Zofran can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS.
What should you not take with Zofran?
Some products that may interact with this drug are: apomorphine, tramadol. Many drugs besides ondansetron may affect the heart rhythm (QT prolongation), including dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others.
How quickly does Zofran work?
Zofran (ondansetron) should work pretty quickly. Many people report relief within about 30 minutes and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.
Who should not use ondansetron?
Ondansetron is not approved for use by anyone younger than 4 years old. Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Can Zofran cause bowel obstruction?
If you are having any of these symptoms you should contact your provider. Because ondansetron manages nausea and vomiting and these are possible side effects of a bowel obstruction, an ileus or bowel obstruction could be occurring and overlooked.
Can you take Zofran every 5 hours?
#1 Ondansetron ( Zofran) You may take one 8 mg tablet every 6 hours. If your nausea does not ease by 30 minutes after taking Zofran, take medicine #2, prochlorperazine (Compazine).
Who Cannot take Zofran?
How long does it take for dissolving Zofran to work?
The standard tablets that are swallowed will start to work within half an hour to 2 hours. Medicines generally work faster on an empty stomach, an hour before food or 2 hours after. The orally disintegrating tablets or oral soluble films are absorbed very quickly into the blood stream so start to work rapidly.
What happens if I throw up after taking Zofran?
If you vomit within one hour taking your first Zofran Tablet of each course prescribed to you, you should take the same dose again. If you continue to vomit, tell your doctor.
What does Zofran do to a normal person?
Zofran blocks serotonin, a natural substance in the brain that may contribute to nausea and vomiting. It belongs to a class of drugs called serotonin 5-HT3 receptor antagonists. These drugs are antiemetics, meaning they block nausea and vomiting.
What is the Max dose of Zofran?
Patients with severe liver problems are limited to a maximum dose of 8mg Zofran in 24 hours. Dosage should be determined by your doctor, and depends on your medical conditions, age, and weight. Patients who should not take Zofran may be prescribed an alternate anti-nausea medication.
How many Zofran can you take?
You may need additional doses up to three times a day during treatment or for a few days after treatment of cancer. For chemotherapy, a typical adult dose of Zofran can range from 16 to 24 mg daily. For radiation therapy, a typical adult dose of Zofran is 24 mg daily.
How often can you take Zofran ODT?
Ondansetron (Zofran) is a prescription medication that can be used for prevention or treatment of nausea and vomiting. Zofran is often prescribed every 8 hours as needed for a maximum of 24 mg per day. Information About Zofran Dosing And Use.