What is Zytiga 250 mg?

What is Zytiga 250 mg?

ZYTIGA is a prescription medicine that is used along with prednisone. ZYTIGA is used to treat men with prostate cancer that has spread to other parts of the body.

What is abiraterone acetate 250 mg?

This medication is used to treat prostate cancer. Abiraterone belongs to a class of drugs known as anti-androgens (anti-testosterone). Testosterone, a natural hormone, helps prostate cancer to grow and spread.

Can I take abiraterone without prednisone?

Conclusions: Treatment with abiraterone acetate without steroids is feasible, although clinically significant adverse events can occur in a minority of patients. The use of abiraterone acetate without prednisone should be balanced with the potential for toxicity and requires close monitoring.

How long can you take abiraterone for?

Life expectancy: The studies show that abiraterone acetate can prolong life. In the larger study, about 50 out of 100 men who had the standard treatment were still alive after 3 years, while after the same period of time 70 out of 100 men who had treatment with abiraterone acetate were still alive.

What happens when you stop taking Zytiga?

Stop taking Zytiga® and see a doctor immediately if you notice signs of low blood potassium: muscle weakness. muscle twitches.

Does Zytiga make you tired?

The most common side effects of ZYTIGA® include: Feeling very tired. Joint pain. High blood pressure.

How does abiraterone acetate work?

Abiraterone acetate works by inhibiting specific “enzymes” in your adrenal glands that are responsible for making androgens. For this reason, there is an increased risk of over production of mineralcorticosteroids in your body while on abiraterone acetate.

When is the best time to take abiraterone?

It is best to take this medicine on an empty stomach, 1 hour before or 2 hours after a meal. Your doctor may also give you other medicines (eg, gonadotropin-releasing hormone medicine) during treatment with abiraterone or you should have had surgical removal of the testes before using this medicine.

Why does abiraterone need to be given with prednisone?

The administration of abiraterone acetate with glucocorticoids is necessary to manage adverse events related to mineralocorticoid excess, such as hypokalemia, hypertension, and fluid retention, which can occur as a result of CYP17A1 inhibition [6–8].

Why do you take prednisone with Zytiga?

Zytiga blocks the production of cortisol from your adrenal glands. Prednisone helps to replace the lost cortisol that can cause side effects such as low blood potassium levels, fluid build up (edema), high blood pressure or irregular heartbeats.

Does abiraterone affect the immune system?

Abiraterone doesn’t affect your immune system or involve regular hospital visits. For this reason, abiraterone may be safer for you than chemotherapy until the risk from coronavirus in the UK has reduced.

How effective is abiraterone acetate?

The pooled analysis reported abiraterone acetate showed significant efficacy in high-risk prostate cancer patients, including overall survival (OS) [HR 0.66, 95% confidence interval (CI), 0.61–0.73, P<0.001], the time to prostate-specific antigen (PSA) progression (HR 0.45, 95% CI, 0.34–0.59, P<0.001), progression-free …

What’s the difference between abiraterone 250 mg and 500 mg?

Abiraterone acetate tablets USP, 250 mg are white to off-white, oval-shaped, uncoated tablets debossed with “AN65” on one side and plain on the other side. Abiraterone acetate tablets USP, 500 mg are purple, oval-shaped, film-coated tablets debossed with “1754” on one side and plain on the other side.

How often should I take abiraterone acetate tablets?

The recommended dose of Abiraterone acetate tablets is 1,000 mg (four 250 mg tablets) orally once daily with prednisone 5 mg orally twice daily.

How much abiraterone is in a Zytiga tablet?

Abiraterone is an inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase). Each ZYTIGA tablet contains either 250 mg or 500 mg of abiraterone acetate. Abiraterone acetate is designated chemically as (3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate and its structure is: Abiraterone acetate is a white to off-white, non-hygroscopic, crystalline powder.

What are the inactive ingredients in abiraterone tablets?

Abiraterone acetate tablets are available in 250 mg uncoated tablets and 500 mg film-coated tablets with the following inactive ingredients: 250 mg uncoated tablets: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate.