What is normal inhibin B?
The normal range of inhibin in post-menopausal women is < 5 pg ml-1, in pre-menopausal women 2-80 pg ml-1 (2-10 pg ml-1 in the follicular phase, 40-80 pg ml-1 in the luteal phase).
What does inhibin B do?
Inhibin B is a hormone associated with reproduction and the development of eggs in women and sperm in men. This test measures the inhibin B level in the blood and may be used as part of an infertility evaluation. Inhibin B is made mostly by the ovaries in females, and by the testicles in males.
Where is inhibin B produced?
ovary
Inhibin B, produced by granulosa cells in the ovary, is a heterodimeric glycoprotein suppressing synthesis and secretion of the follicle stimulating hormone (FSH).
What is the difference between inhibin A and inhibin B?
Inhibin A is low in the early follicular phase and rises at ovulation to maximum levels in the mid-luteal phase. In contrast, inhibin B levels increase early in the follicular phase to reach a peak coincident with the onset of the mid-follicular phase decline in FSH levels.
What does inhibin B do in females?
The main function of inhibin in women is regulation of pituitary FSH secretion. One study showed that a decrease in serum inhibin concentrations could be observed when the ovarian follicular reservoir begins to diminish.
What is inhibin B in males?
Inhibin B is a dimer of an alpha and a betaB subunit. It is produced exclusively by the testis, predominantly by the Sertoli cells in the prepubertal testis, while the site of production in the adult is still controversial. Inhibin B controls FSH secretion via a negative feedback mechanism.
Do females have inhibin?
Inhibin is a protein secreted by the Sertoli cells in men and by the granulosa cells in women.
What causes high inhibin B levels?
Elevated levels of inhibin A and/or inhibin B may be present in the blood of a woman with a rare type of ovarian tumor called a granulosa cell tumor (the most common type of sex-cord stromal tumor). Blood levels of these hormones may also be elevated in some women with mucinous epithelial tumors.
What does high inhibin B mean?
What does inhibin A test for?
Inhibin A Test is a basic blood test that measure the level Inhibin A in the blood. It is used in pregnant women who are suspected of carrying a foetus with down syndrome. The Inhibin A test is also used for the diagnosis of Granulosa cell tumours and Mucinous Epithelial Ovarian Tumour.
What is FSH in males?
In men, FSH helps control the production of sperm. Normally, FSH levels in men do not change very much. In children, FSH levels are usually low until puberty, when levels begin to rise. In girls, it helps signal the ovaries to make estrogen. In boys, it helps signal the testes to make testosterone.