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What does the Nanog gene do?

What does the Nanog gene do?

NANOG is a transcription factor that is involved in the self-renewal of embryonic stem cells (ES). It was first discovered by Chambers et al. and Mitsui et al. in mouse ES cells and described as an important transcription regulator that both activates the repressors and suppresses the activators of differentiation.

What is Nanog expression?

Cancer stem cells Nanog is a transcription factor that controls both self-renewal and pluripotency of embryonic stem cells. Similarly, the expression of Nanog family proteins is increased in many types of cancer and correlates with a worse prognosis.

What is KLF4 gene?

KLF4 (Kruppel Like Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Secretory Meningioma and Cerebral Cavernous Malformations. Among its related pathways are Developmental Biology and Regulation of Wnt-mediated beta catenin signaling and target gene transcription.

What type of pseudogene is NANOGP1?

unprocessed pseudogene
NANOGP1 is an unprocessed pseudogene that arose from duplication of a segment of chromosome 12, and thus may have remained functional for an undetermined period of time after its formation.

Who discovered Nanog gene?

Prof Ian Chambers
The team was led by CRM Group Leader Prof Ian Chambers who discovered the fundamental role of Nanog in supporting stem cell pluripotency, the ability to produce any type of cell in the human body. In Embryonic Stem Cells, the effects of the Nanog gene are mediated in part by a second gene Essrb.

What is SSEA4?

SSEA4 is a carbohydrate epitope of glycoproteins expressed during early development and is a marker of human embryonic stem cells. 17. The presence of SSEA4 synthase is an indicator of SSEA4 synthesis.

Is KLF4 an oncogene?

KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.

What is Yamanaka factor?

The Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are a group of protein transcription factors that play a vital role in the creation of induced pluripotent stem cells (cells that have the ability to become any cell in the body), often called iPSCs. They control how DNA is copied for translation into other proteins.

Is Sox2 a protein?

Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.

What is the function of the NANOG gene?

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells.

How is NANOG related to colorectal cancer stem cells?

RNAi mediated silencing of Nanog expression suppresses the growth of human colorectal cancer stem cells. Title: RNAi mediated silencing of Nanog expression suppresses the growth of human colorectal cancer stem cells. NANOG/NANOGP8 Localizes at the Centrosome and is Spatiotemporally Associated with Centriole Maturation.

Which is a direct NANOG target gene in pluripotent cells?

“Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells.” “Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human.” Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

How does NANOG enhance the proliferation of fibroblasts?

Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 gene. The different embryonic stem cells Nanog-expressing populations differ in their differentiation propensities. Nanog upregulation is not well correlated to Oct4, Sox2 and Klf4 expression, or cell cycle phase.