Is familial adenomatous polyposis rare?
Familial adenomatous polyposis (FAP) is a rare, inherited condition caused by a defect in the adenomatous polyposis coli (APC) gene. Most people inherit the gene from a parent. But for 25 to 30 percent of people, the genetic mutation occurs spontaneously.
How often should you have a colonoscopy if polyps are found?
If your doctor finds one or two polyps less than 0.4 inch (1 centimeter) in diameter, he or she may recommend a repeat colonoscopy in five to 10 years, depending on your other risk factors for colon cancer. Your doctor will recommend another colonoscopy sooner if you have: More than two polyps.
How does familial adenomatous polyposis affect the body?
Familial adenomatous polyposis (FAP) is a rare, inherited condition caused by a defect in the adenomatous polyposis coli (APC) gene. Most people inherit the gene from a parent. But for 25 to 30 percent of people, the genetic mutation occurs spontaneously. FAP causes extra tissue (polyps) to form in your large intestine (colon) and rectum.
When do you need surgery for adenomatous polyposis?
If untreated, the polyps in the colon and rectum are likely to become cancerous when you are in your 40s. Most people with familial adenomatous polyposis eventually need surgery to remove the large intestine to prevent cancer.
How are APC mutations related to adenomatous polyposis?
These mutations affect the ability of the cell to maintain normal growth and function. Cell overgrowth resulting from mutations in the APC gene leads to the colon polyps seen in familial adenomatous polyposis.
Can a person with Gardner syndrome have polyps?
People who have colon polyps as well as growths outside the colon are sometimes described as having Gardner syndrome. A milder type of familial adenomatous polyposis, called autosomal recessive familial adenomatous polyposis, has also been identified.