What type of drug is benzoylecgonine?
Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver.
What schedule drug is benzoylecgonine?
Benzoylecgonine is regulated as a Schedule II compound in the United States.
Is benzoylecgonine acidic or basic?
Properties
| Property | Value | Source |
|---|---|---|
| pKa (Strongest Acidic) | 3.15 | ChemAxon |
| pKa (Strongest Basic) | 9.54 | ChemAxon |
| Physiological Charge | 0 | ChemAxon |
| Hydrogen Acceptor Count | 4 | ChemAxon |
What are the effects of benzoylecgonine?
Benzoylecgonine-induced vasoconstriction appeared to be mediated through alpha-adrenergic stimulation, predominantly through stimulation of alpha 1-adrenergic receptor subtypes. We conclude that cocaine and benzoylecgonine cause significant fetal cerebral artery vasoconstriction in vitro.
What can make you test positive for benzoylecgonine?
There is an isolated report of antibody-mediated interference in EMIT for benzoylecgonine. However, true positive test results may occur due to drinking herbal tea containing cocaine or application of cocaine as an anesthetic agent during ENT surgery.
What drugs can cause a false positive for benzoylecgonine?
Drugs that can cause false positives
- 1) Dextromethorphan. Dextromethorphan is an active ingredient in Robitussin, Delsym, and other over-the-counter cough suppressants.
- 2) Diltiazem.
- 3) Diphenhydramine.
- 4) Metformin.
- 5) Pseudoephedrine.
- 6) Labetalol.
- 7) Methylphenidate.
- 8) Doxylamine.
What over the counter drugs will test positive for benzodiazepines?
According to URMC, the following drugs may cause a false positive result in benzodiazepine urine tests:
- etodolac (Lodine)
- fenoprofen (Nalfon)
- naproxen (Aleve)
- oxaprozin (Daypro)
- sertraline (Zoloft)
- tolmetin (Tolectin)
What is benzoylecgonine drug test?
Urinalysis. Benzoylecgonine is the compound tested for in most substantive cocaine drug urinalyses. It is the corresponding carboxylic acid of cocaine, its methyl ester. It is formed in the liver by the metabolism of cocaine by hydrolysis, catalysed by carboxylesterases, and subsequently excreted in the urine.
What drugs can cause a false-positive for benzoylecgonine?
Can sertraline cause a false-positive for benzodiazepines?
Of the selective serotonin reuptake inhibitors (SSRIs), sertraline has been reported to cause false-positive results for benzodiazepines and lysergic acid diethylamide (LSD),1-4,9 and fluoxetine has been reported to cause false-positive results for LSD and amphetamines.
What will cause a false positive for benzodiazepines?
A search of false positive benzodiazepine screenings showed the selective serotonin reuptake inhibitor (SSRI) sertraline (Zoloft, others) and the non-steroidal anti-inflammatory drug (NSAID) oxaprozin (Daypro, others) to be associated with, or possible causes of, these false-positive results.
How long does benzoylecgonine stay in your urine?
For people who use the drug on a sporadic basis, benzoylecgonine can remain in the urine for up to 5 days following infrequent use, up to 7 days with high doses, and for up to 14 days with chronic use.
How long does benzoylecgonine stay in blood?
Cocaine is eliminated from your blood within 4 – 6 hours, whereas benzoylecgonine can be present for up to 6 days after administration. Benzoylecgonine is detectable in your blood within 30 minutes of cocaine consumption.
What does benzoylecgonine mean?
Medical Definition of benzoylecgonine. : a metabolite C 16H 19NO 4 of cocaine that is found in the blood and urine Drug levels were determined from benzoylecgonine, a chemical by-product of cocaine found solely in the urine of users.
How long is benzoylecgonine detectable?
The widely accepted time period for benzoylecgonine to be cleared from the urine is three to five days. One study suggests that high dose users (i.e., 0.5 gram or greater for each episode of use) can test positive after eight days.