What is the blood-brain barrier and what is its function?
The purpose of the blood–brain barrier is to protect against circulating toxins or pathogens that could cause brain infections, while at the same time allowing vital nutrients to reach the brain.
What is the brain blood barrier?
The blood-brain barrier is a multicellular, compound structure composed of endothelial cells, pericytes and astrocytes in direct contact with brain tissue. The BBB is a compound structure following the brain’s labyrinth of vasculature. It’s composed of 4 cell types: Endothelial Cells.
What is the structure of the blood-brain barrier?
The blood-brain barrier is the barrier between the cerebral capillary blood and the interstitial fluid of the brain. It is made up of capillary endothelial cells and basement membrane, neuroglial membrane, and glial podocytes, i.e., projections of astrocytes.
What causes damage to the blood-brain barrier?
So what happens if the blood–brain barrier is damaged or somehow compromised? One common way this occurs is through bacterial infection, as in meningococcal disease. Meningococcal bacteria can bind to the endothelial wall, causing tight junctions to open slightly.
Does caffeine cross the blood-brain barrier?
We studied the transport of 14C-caffeine across the blood-brain barrier (BBB) by measuring brain 14C:3H ratios five seconds after rats received the caffeine, with 3H2O, by intracarotid injection. Caffeine was found to enter the brain by both simple diffusion and saturable, carrier-mediated transport.
Does Sugar cross the blood-brain barrier?
Glucose is the primary energy substrate of the brain. Glucose transport protein (GLUT-1) is highly enriched in brain capillary endothelial cells. These transporters carry glucose molecules through the blood brain barrier.
What infections can cross the blood-brain barrier?
Many neurotropic viruses can cross the BBB via a hematogenous route and eventually invade the CNS, such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), West Nile virus (WNV), tick-borne encephalitis virus of the Flaviviridae,6 Eastern, Western, Venezuelan equine encephalitis viruses of the Togaviridae,7 HIV of …
What drugs Cannot cross the blood-brain barrier?
(A) Passive diffusion: fat-soluble substances dissolve in the cell membrane and cross the barrier (e.g., alcohol, nicotine and caffeine). Water-soluble substances such as penicillin have difficulty in getting through.
What foods cross the blood-brain barrier?
Lower stress hormones. Increase the brain’s growth hormone. Reduce hyper-permeability of the blood-brain barrier….Strong dietary sources of magnesium include:
- Pumpkin seeds.
- Dark chocolate.
Does ibuprofen cross the blood-brain barrier?
Ibuprofen is a lipophilic compound that crosses the blood-brain barrier (BBB) (Parepally et al., 2006; Kokki et al., 2007).
Can alcohol cross the blood-brain barrier?
The connection between the blood-brain barrier and alcohol exists because alcohol is able to cross through the blood-brain barrier by moving via blood circulation to the brain cells. This, of course, can result in the death of many brain cells, which can negatively impact a person’s health and cognitive performance.
Which foods cross the blood-brain barrier?