What drugs are metabolised by CYP2D6?
Multiple tricyclic antidepressants, β blockers, haloperidol, sertraline, paroxetine, and thioridazine are among the common drugs metabolized by CYP2D6.
What drugs are metabolized by CYP?
Examples of Common Drug-Drug Interactions Involving the Cytochrome P450 Enzyme System
| Drug(s)/product | Enzyme inhibitor or inducer | Drug(s) |
|---|---|---|
| Grapefruit juice | CYP3A4 inhibitor | Buspirone (Buspar) |
| Metronidazole (Flagyl) | CYP2C9 inhibitor | Warfarin |
| Terbinafine (Lamisil) | CYP2D6 inhibitor | Amitriptyline |
What opioids are metabolized by CYP2D6?
Oral opiates (e.g. codeine, oxycodone, and hydrocodone) are metabolized by cytochrome CYP2D6 to metabolites of increased activity (e.g. morphine, oxymorphone and hydromorphone).
Which drugs are metabolised by cyp450?
Among the drugs metabolized are sedatives such as midazolam, triazolam and diazepam, the antidepressives amitriptyline and imipramine, the anti-arryhthmics amiodarone, quinidine, propafenone and disopyramide, the antihistamines terfenadine, astemizole and loratidine, calcium channel antagonists such as diltiazem and …
What is CYP2D6 * 2A?
Thus, genotype CYP2D6*1/CYP2D6*2A is indicative of a normal enzymatic activity that can be assigned to the extensive metabolizers (EMs).
Which drugs are metabolized by CYP3A4?
Cytochrome P450 enzymes metabolize approximately 60% of prescribed drugs, with CYP3A4 responsible for about half of this metabolism; substrates include acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin. The enzyme also metabolizes some steroids and carcinogens.
What enzyme metabolizes oxycodone?
Oxycodone is primarily metabolized in the liver by the cytochrome P450 (CYP) enzymes with CYP3A as the major metabolic pathway and CYP2D6 as the minor metabolic pathway to noroxycodone, oxymorphone and noroxymorphone. Oxycodone exerts its analgesic effect via the µ-opioid receptor.
What are cytochrome P450 drugs?
The cytochrome P450 (CYP450) enzymes are essential to produce numerous agents, including cholesterol and steroids. They are also necessary for the detoxification of foreign chemicals and metabolism of drugs. Drugs that cause CYP450 drug interactions are referred to as either inhibitors or inducers.