What does the Sonic hedgehog gene do?
The SHH gene provides instructions for making a protein called Sonic Hedgehog. This protein functions as a chemical signal that is essential for embryonic development. Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping (patterning) of the body.
Is the Sonic hedgehog gene real?
Sonic hedgehog is a protein encoded for by the SHH gene. This signaling molecule is key in regulating embryonic morphogenesis in all different types of animals.
Why is gene called Sonic hedgehog?
Sonic was named as such by the Harvard researcher (Cliff Tabin) because two previous gene family members had been named Indian and dessert hedgehog based on the way fruit flies looked when these gene were mutated.
What does Sonic hedgehog bind to?
When SHH reaches its target cell, it binds to the Patched-1 (PTCH1) receptor (Process “3” on Figure 5, the blue molecule).
Who named Shh?
The story of Shh is told a lot, but it’s surprisingly difficult to track down the real story. Though some sources credit Dr. Cliff Tabin with naming the Sonic hedgehog gene, it actually came from another scientist in his lab.
Is Shh a Hox gene?
The Hox gene network has multiple roles in vertebrate limb development. Another function of Hox genes that has emerged recently is to regulate expression of the Sonic hedgehog gene (Shh) which controls patterning of distal structures. Hox genes also play a major role in development of the digits.
What inhibits Sonic hedgehog?
Shh Inhibitors Sonic Hedgehog (Shh) is the most potent of the three Hedgehog ligands. Inhibition of Shh expression and activity can thus be an effective way of restricting Hedgehog signaling-mediated tumor progression. RU-SKI 43 inhibits the activity of SHHat, an enzyme that catalyzes the palmitoylation of Shh.
How was SHH named?
The mammalian hedgehog protein, sonic hedgehog (SHH) was named by a postdoc in Cliff Tabin’s lab who took inspiration from a comic book his daughter was reading. SHH is involved in the hedgehog signalling pathway, which is a key regulator of all bilateral animal development.
What is SHH mean?
quiet be
Ways of telling someone to stop talking or to be quiet. be quiet. keep your voice down. shh.