How is formulation development of parenteral products achieved?
Formulation development studies achieve those optimal conditions through either the use of additives or the manner in which the drug is processed.
Can a large volume of parenteral be dangerous?
Large volume parenteral must not contain preservative becoz it may be dangerous to human body if it contain in high doses. Buffers: Added to maintain pH, Change in pH may causes degradation of the products Acetates, citrates, phosphates are generally used.
Which is the most stable form of parenterals?
Stabilizers: As parenterals are available in solution form they are most prone to unstabilize Used to stabilize the formulation Maintain stable Examples: Creatinine 0.5- 0.8 % Glycerin 1.5 2.25 % Niacinamide 1.25 -2.5 % Sodium saccharin 0.03 %
When to use parenteral route of Drug Administration?
Drugs are also administered by the parenteral route if a targeted part of the body needs treatment. For example, if a patient is having issues with a knee, drugs can be injected directly into the knee for maximum effect.
Are there Preformulation studies for a parenteral solution of memantine?
Preformulation studies regarding a physico-chemical evaluation of memantine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, are presented in this work. This characterization of memantine is pre-required for the formulation of a parenteral solution.
What are the different types of parenteral preparations?
The United States Pharmacopeia (USP) defines five main types of preparations intended for parenteral administration: Injection: liquid preparations that are drug substances or solutions thereof For injection: dry solids that, upon addition of suitable vehicles, yield solutions conforming in all respects to the requirements for injections
What does parenteral mean in the medical category?
Parenteral:a route of administration of a substance into the body other than through the mouth, eyes, or skin Process Compatibility:testing performed in order to understand the interaction of an active pharmaceutical ingredient in a formulated product with components that it contacts during manufacturing