What is the difference between Enantiotopic and enantiomers?
It is achiral because its two methyl groups are equivalent. These two methyl groups are therefore enantiotopic….Prochirality and axial chirality.
| a face, atom or group is… | if its replacement leads to… | distinguishable? |
|---|---|---|
| enantiotopic | enantiomers | in a chiral environment |
What is homotopic and heterotopic?
Compare the two structures formed. If they are identical, the protons are homotopic, if they are enantiomers, the protons are enantiotopic, if they are diastereomers then the protons are diastereotopic, if they are structural isomers, the protons are constitutionally heterotopic.
What are Enantiotopic ligands and faces?
The carbon of the carbonyl group has a hydrogen, carbon (as phenyl) and oxygen attached to it in a trigonal arrangement. The faces of this molecule are said to be enantiotopic because any achiral nucleophile that is not H, phenyl or OH leads to two enantiomers.
How is Enantiotopic calculated?
To determine the relationship of these protons, remember that symmetry axis means homotopic, and if there is no axis, but a there is a plane of symmetry, then the protons are enantiotopic. If the protons are not related by these symmetry elements, they are not equivalent and will give two NMR signals.
What are Enantiotopic?
Enantiotopic. The stereochemical term enantiotopic refers to the relationship between two groups in a molecule which, if one or the other were replaced, would generate a chiral compound. The two possible compounds resulting from that replacement would be enantiomers.
What does heterotopic mean?
1 : occurring in an abnormal place heterotopic bone formation. 2 : grafted or transplanted into an abnormal position heterotopic liver transplantation.
What are Diastereotopic hydrogens?
4 Diastereotopic hydrogens (or groups) If the replacement in turn of each of two identical atoms (or groups) attached to a non-stereogenic centre gives different diastereoisomers, the atoms (or groups) are diastereotopic. It is important to recognise when a CH2 group is diastereotopic and when it is not.
What are Enantiotopic hydrogens?
2 Enantiotopic hydrogens (or groups) Two hydrogens (or other groups) in an achiral or meso compound that are equivalent because of a mirror plane are enantiotopic if replacing one of them with a different group leads to a chiral molecule.
What is the treatment for heterotopic ossification?
Usually, treatment will include gentle range of motion of the joints and some physical therapy. Your doctor may also prescribe medications to slow down or stop the abnormal growth of bone. When HO severely affects your movement or causes excruciating pain, surgery may be needed.