Is Panobinostat a chemotherapy drug?
Panobinostat is used to treat multiple myeloma. It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.
Is Panobinostat FDA approved?
The Food and Drug Administration (FDA) has granted accelerated approval of panobinostat (Farydak) for the treatment of patients with multiple myeloma whose cancer has progressed after treatment with at least two prior standard therapies. Panobinostat is a type of drug called a histone deacetylase (HDAC) inhibitor.
What do HDAC inhibitors do?
Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis, and cell cycle arrest in cancer cells.
Who manufactures Farydak?
FARYDAK [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2016. 2.
What type of drug is Panobinostat?
Drug Type: Panobinostat is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Panobinostat is classified as a “Histone Deacetylase (HDAC) Inhibitor”.
How does Marizomib work?
Marizomib is a small molecule that inhibits a large protein complex called the proteasome whose role is to degrade abnormally folded or damaged proteins. The proteasome also regulates several proteins involved in cell growth, cell division, and cell survival.
When was Panobinostat approved by the FDA?
Development Timeline for Farydak
| Date | Article |
|---|---|
| Feb 23, 2015 | Approval FDA Approves Farydak (panobinostat) for Multiple Myeloma |
| Nov 6, 2014 | Novartis Announces Outcome of FDA Advisory Committee Meeting for LBH589 (Panobinostat) |
What drugs are HDAC inhibitors?
To date, the United States Food and Drug Administration (US FDA) has approved four HDAC inhibitors for the anti-cancer drugs: Vorinostat, Romidepsin, Belinostat, and Panobinostat (Table 1).
How is Xpovio given?
How is XPOVIO administered? In the Xd regimen, XPOVIO is given orally at a dose of 80 mg along with dexamethasone (20 mg orally) twice a week (both drugs on days 1 and 3 of a 28-day cycle) until disease progression.
Is Panobinostat cytotoxic?
Panobinostat is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Panobinostat is classified as a “Histone Deacetylase (HDAC) Inhibitor”.
How is Panobinostat administered?
Panobinostat should be administered orally once daily on scheduled days only, at the same time each day. The capsules should be swallowed whole with water, with or without food, and they should not be opened, crushed or chewed. If a dose is missed, it can be taken up to 12 hours after the specified dose time.